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The principal cytochrome P450 isoenzyme involved appears to be CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Around 85% of the oral dose appears from the urine in just 24 hours of administration, most because the glucuronide conjugate, with tiny quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity data.Usually do not